Systemic Sclerosis

SSc hands hi res

Current treatment measures Systemic sclerosis (SSc) is an autoimmune disease characterised by immune dysregulation, excessive fibrosis and vascular changes that can affect multiple organs. There are two subtypes: limited (LcSSc) and diffuse (DcSSc) cutaneous SSc. In LcSSc, fibrosis is mainly restricted to the fingers, hands, face, forearms (distal to the elbows) and lower legs (distal […]

Ankylosing Spondylitis


Managing an incurable condition Spondyloarthritis defines a group of diseases that have many features in common, and these include familial clustering, HLA-B27 positivity, inflammatory back pain, sacroiliitis, asymmetric peripheral arthritis, enthesitis, and extra-articular manifestations such as uveitis, inflammatory bowel disease and psoriasis. Ankylosing spondylitis (AS) is the prototype in the group, which includes psoriatic arthritis, […]

The Use of Ultrasound in Rheumatoid Arthritis

doctor studying a knee joint

Beyond conventional x-rays This article provides clinicians with an insight into the value and applicability of ultrasound (US) in Rheumatoid Arthritis (RA), and outlines the clinical scenarios which may benefit from US imaging. Management of Rheumatoid Arthritis RA is a progressive and disabling autoimmune disease characterised by inflammation of the synovial lining at the joints […]

Systemic Lupus Erythematosus


A diagnosis not to be missed Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease which may affect the skin, joints, kidneys, lungs, heart, central nervous system and blood. It is more common in females than males with a ratio of 9:1, often affecting women of reproductive age.1 The incidence of SLE ranges from one […]

Immunocompromised State in Focus


The immune system helps our body fight back infections and diseases. Foreign “invaders” which are primarily microbes – bacteria, parasites, and fungi – that can cause infections are attacked by the immune system cells while ignoring healthy tissue. In the event that the immune system is weakened or compromised, the body becomes vulnerable to these […]

Childhood Asthma – Classification, Evaluation and Management


Childhood Asthma Classification, evaluation and management of the condition Dr Arun Kumar Pugalenthi  Asthma is a heterogeneous disorder in children that is characterised by recurrent airway obstruction, bronchial hyper-responsiveness and airway inflammation. Many clinical aspects are variable from individual to individual. World Health Organisation (WHO) estimates that about 235 million people in the world currently […]

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