Scientists at A*STAR’s Institute of Molecular and Cell Biology (IMCB) have made a landmark discovery suggesting that, contrary to the current accepted theory that antibodies can only bind to cancer proteins found on the cancer cell surface, antibodies can in fact directly target intracellular oncoproteins e.g. PRL-3 which reside within the cancer cells to suppress [...]
Cancer: Principles & Practice of Oncology Primer of the Molecular Biology of Cancer Authors: Vincent DeVita, Ronald A. DePinho, Theodore S. Lawrence, Steven A. Rosenberg, Robert A. Weinberg Publisher: Lippincott Williams & Wilkins “Cancer: Principle and Practice of Oncology” in the era of personalised cancer medicine: I can really confirm this textbook as the standard-setting [...]
Women over the age of 30 who test positive for human papillomavirus (HPV) should be re-tested two years later as part of cervical cancer screening, according to a Taiwanese first published online on September 6 in the Journal of the National Cancer Institute. Researchers from the Genomics Research Center of Academia Sinica in Taipei, Taiwan, [...]
AvastinTM significantly improved tumour response rates among breast cancer patients when added to preoperative chemotherapy, according to the results of a Phase III clinical trial presented at the annual meeting of the American Society of Clinical Oncology. This development comes after the US Food and Drug Administration ruled that AvastinTM should not be used to [...]
An advanced radiation therapy technique called Intensity Modulated Radiation Therapy (IMRT) produced a high response rate and kept side effects at a minimum in patients with extranodal lymphoma of the head and neck, according to new research from the Fox Chase Cancer Center. The study identified five patients with extranodal lymphoma of the head and [...]
A new study shows that nearly half of breast cancer patients with BRCA1 gene mutation experienced a complete pathological response (pCR), i.e. the disappearance of all evidence of disease from the breast tissue and lymph nodes, regardless of disease stage following standard neoadjuvant chemotherapy. The study by researchers from the University of Texas MD Anderson [...]
Elderly patients with advanced non-small-cell lung cancer (NSCLC) live longer with combination chemotherapy than with the currently recommended monotherapy, researchers reported online in The Lancet. The randomised trial enrolled 451 patients aged 70 to 89 years with locally advanced or metastatic disease, and World Health Organization performance status scores of two or lower. They were [...]
Once-daily oral abiraterone acetate (ZytigaTM, Centocor Ortho Biotech Inc) was recently approved by the US FDA for use in combination with prednisone for the treatment of metastatic castration-resistant prostate cancer, in patients who have received prior chemotherapy containing docetaxel. Androgen can help fuel the tumour’s growth in prostate cancer. ZytigaTM works by inhibiting the CYP17 [...]
According to case-control study findings published online in August in the journal Cancer, people who smoke within half an hour of waking up were at a 59 percent higher risk for head and neck cancer and 79 percent elevated risk for lung cancer, as compared with those who waited at least an hour. The study [...]
When treating laryngeal cancer, the choice of treatment not only depends on the stage of the tumour, but also factors such as age, general well-being and job nature of the patient. For example, larynx preservation is an important treatment option for patients who want to preserve their voice, according to Dr Tan Lye Suan, consultant [...]